During 28 February-1 March 2021, large-scale anti-coup protests occurred throughout Myanmar amid a significant government security force presence. In Yangon, large-scale protests occurred on 1 March, including along Insein Road in Hlaing district, Sanchaung district and Hledan Junction Skyway. Elsewhere, individuals participated in marches in the city of Mandalay and gathered at funerals for protesters killed during the weekend in the cities of Mandalay and Mawlamyine, the capital of Mon state, located approximately 160 km (100 mi) southeast of Yangon.

In response, security forces used live ammunition, stun grenades and tear gas to disperse protests in areas throughout Yangon. Various reports indicate that protesters across the country constructed barricades and homemade shields to prevent security forces from charging protesters and to protect from stun grenades and rubber bullets. Security forces killed at least nine protesters and wounded several more as they sought to disperse the protests. Reports indicate security forces also detained several dozen protesters and bystanders. Internet access for the entire country has been restricted on multiple days during 0100-0900 local time (1830-0230 UTC).