On 10 April 2022, Prime Minister Imran Khan was voted out of office by the National Assembly in a no-confidence vote of 174-0 after the Supreme Court invalidated an earlier attempt to dismiss parliament by the deputy speaker in an attempt to postpone the vote. In related developments, on 10 April, tens of thousands of Khan supporters gathered nationwide — including in the capital city Islamabad, plus Lahore, Mianwali, Multan, Sheikhupura and Taxila — to express support for the former prime minister. In Islamabad, tens of thousands of Pakistan Tehreek-e-Insaf (PTI) party and Khan supporters gathered near the city center. There were no reports of large-scale violence or arrests. In the eastern city of Lahore, thousands of residents gathered near Lalik Jan Chowk and Liberty Market and shouted slogans denouncing the U.S. government. Additionally, in the southern city of Karachi, a large protest was held near Rashid Minhas road and the at the Millennium Mall.

The Pakistani Federal Investigation Agency (FIA) has placed all immigration staff at all airports on high alert to prevent government officials from leaving the country. The FIA declaration was issued shortly after the no-confidence vote that removed Prime Minister Khan from power. Until further notice, only government officials holding a No-Objection Certificate will be allowed to leave the country.